Ai care Assistant
Clinical Trials
Meet Cali
Cali runs your participant contact between visits, by phone. No app, no portal, no device required. Flows, cadence, and escalation rules set to your protocol.
Cali runs your participant contact between visits, by phone. No app, no portal, no device required. Flows, cadence, and escalation rules set to your protocol.
Cali runs your participant contact between visits, by phone. No app, no portal, no device required. Flows, cadence, and escalation rules set to your protocol.
25
+
Conditions Covered
25
+
Conditions Covered
100
%
Interactions Auditable
100
%
Interactions Auditable
100+
Languages Supported
100+
Languages Supported
Problem
Care teams cannot track every participant continuously.
By the time disengagement shows up, it's already a dropout.
Participant dropout: Disengagement is gradual and often silent. Without regular contact, withdrawal decisions are made before the study team has any opportunity to respond.
Gaps between visits: Weeks pass between site contacts. Participant experiences go unrecorded and study teams lose visibility into what's happening in between.
Coordinator capacity: Manual follow-up calls, reminders, and documentation consume significant coordinator time & money, time that scales poorly across large or multi-site studies.
What we Offer
Cali works across your entire study. From first contact to final follow-up.
Every deployment is configured to your protocol, your population, and your data requirements.
Between Visits
Participant Contact & PRO Capture
Cali contacts participants on the protocol schedule in their own language. Symptoms, adherence, and mood captured conversationally, the way self-completed diaries never quite manage.
Cali
Hi Margaret, how are you feeling since your last visit?
What Cali captures:
Symptoms, adherence, and mood at protocol cadence
PROs in the participant's own words
Missed contacts and protocol deviations
Safety Monitoring
Adverse Event Capture Between Visits
Scheduled conversations between visits surface safety signals earlier. Escalation when defined thresholds are crossed. Higher signal density without adding coordinator burden.
Concerning Call
Margaret
3m ago
Participant reported dizziness. Escalation triggered.
Flagging for coordinator review
What Cali captures:
Adverse events and symptom changes between visits
Threshold breaches that trigger coordinator escalation
Full timestamped record of every interaction
Multi-Site & Global Studies
Consistent Engagement Across Every Site
The same protocol cadence, delivered identically across every site and every country. No variation in contact quality, no variation in data.
Dallas, TX
English
Miami, FL
English, Spanish, Haitian Creole
Queens, NY
English, Mandarin, Korean
What Cali captures:
Consistent PRO and adherence data across every site
Participant responses in 100+ languages
Protocol deviations and missed contacts flagged automatically
Long-Term Follow-Up
Post-Approval Surveillance & Registries
Where five year follow up was once typical, ten year post approval requirements are increasingly common. Cali keeps participant contact continuous across that longer span, effortlessly and at a fraction of the cost of manual follow up. It makes long term safety monitoring and registries economic to run, and keeps the data complete and audit ready.
Dropout attention
Margaret
Engagement declined over the last 3 check-ins. Shorter responses, missed attempts, lower adherence reporting.
Flagging for coordinator review
What Cali captures:
Safety signals and adherence trends over months or years
Participant reported outcomes that support RWE generation
Audit ready records throughout the follow-up window
What we Offer
Cali works across your entire study. From first contact to final follow-up.
Every deployment is configured to your protocol, your population, and your data requirements.
Between Visits
Participant Contact & PRO Capture
Cali contacts participants on the protocol schedule in their own language. Symptoms, adherence, and mood captured conversationally, the way self-completed diaries never quite manage.
Cali
Hi Margaret, how are you feeling since your last visit?
What Cali captures:
Symptoms, adherence, and mood at protocol cadence
PROs in the participant's own words
Missed contacts and protocol deviations
Safety Monitoring
Adverse Event Capture Between Visits
Scheduled conversations between visits surface safety signals earlier. Escalation when defined thresholds are crossed. Higher signal density without adding coordinator burden.
Concerning Call
Margaret
3m ago
Participant reported dizziness. Escalation triggered.
Flagging for coordinator review
What Cali captures:
Adverse events and symptom changes between visits
Threshold breaches that trigger coordinator escalation
Full timestamped record of every interaction
Multi-Site & Global Studies
Consistent Engagement Across Every Site
The same protocol cadence, delivered identically across every site and every country. No variation in contact quality, no variation in data.
Dallas, TX
English
Miami, FL
English, Spanish, Haitian Creole
Queens, NY
English, Mandarin, Korean
What Cali captures:
Consistent PRO and adherence data across every site
Participant responses in 100+ languages
Protocol deviations and missed contacts flagged automatically
Long-Term Follow-Up
Post-Approval Surveillance & Registries
Where five year follow up was once typical, ten year post approval requirements are increasingly common. Cali keeps participant contact continuous across that longer span, effortlessly and at a fraction of the cost of manual follow up. It makes long term safety monitoring and registries economic to run, and keeps the data complete and audit ready.
Dropout attention
Margaret
Engagement declined over the last 3 check-ins. Shorter responses, missed attempts, lower adherence reporting.
Flagging for coordinator review
What Cali captures:
Safety signals and adherence trends over months or years
Participant reported outcomes that support RWE generation
Audit ready records throughout the follow-up window
What we Offer
Cali works across your entire study. From first contact to final follow-up.
Every deployment is configured to your protocol, your population, and your data requirements.
Between Visits
Participant Contact & PRO Capture
Cali contacts participants on the protocol schedule in their own language. Symptoms, adherence, and mood captured conversationally, the way self-completed diaries never quite manage.
Cali
Hi Margaret, how are you feeling since your last visit?
What Cali captures:
Symptoms, adherence, and mood at protocol cadence
PROs in the participant's own words
Missed contacts and protocol deviations
Safety Monitoring
Adverse Event Capture Between Visits
Scheduled conversations between visits surface safety signals earlier. Escalation when defined thresholds are crossed. Higher signal density without adding coordinator burden.
Concerning Call
Margaret
3m ago
Participant reported dizziness. Escalation triggered.
Flagging for coordinator review
What Cali captures:
Adverse events and symptom changes between visits
Threshold breaches that trigger coordinator escalation
Full timestamped record of every interaction
Multi-Site & Global Studies
Consistent Engagement Across Every Site
The same protocol cadence, delivered identically across every site and every country. No variation in contact quality, no variation in data.
Dallas, TX
English
Miami, FL
English, Spanish, Haitian Creole
Queens, NY
English, Mandarin, Korean
What Cali captures:
Consistent PRO and adherence data across every site
Participant responses in 100+ languages
Protocol deviations and missed contacts flagged automatically
Long-Term Follow-Up
Post-Approval Surveillance & Registries
Where five year follow up was once typical, ten year post approval requirements are increasingly common. Cali keeps participant contact continuous across that longer span, effortlessly and at a fraction of the cost of manual follow up. It makes long term safety monitoring and registries economic to run, and keeps the data complete and audit ready.
Dropout attention
Margaret
Engagement declined over the last 3 check-ins. Shorter responses, missed attempts, lower adherence reporting.
Flagging for coordinator review
What Cali captures:
Safety signals and adherence trends over months or years
Participant reported outcomes that support RWE generation
Audit ready records throughout the follow-up window
Attention Layer
Participant conversations are turned into structured, comparable data across the cohort.
Trends, anomalies, protocol deviations, and dropout risk surface visually in one dashboard.
Conversational Symptoms, adherence, side effects, daily function, emotional and mental state. Captured in the participant's own words.
Conversational Symptoms, adherence, side effects, daily function, emotional and mental state. Captured in the participant's own words.
Conversational Symptoms, adherence, side effects, daily function, emotional and mental state. Captured in the participant's own words.
Analytics Conversations stream in a single dashboard. Trends, anomalies, and protocol deviations surfaced visually.
Analytics Conversations stream in a single dashboard. Trends, anomalies, and protocol deviations surfaced visually.
Attention Layer Participants at risk of dropping out, deviating from protocol, or showing health concerns highlighted automatically for coordinator review.
Liz
Liz
Liz
Why It Works
The case for Cali isn't theoretical.
The case for Cali isn't theoretical.
More participants reached. Less coordinator time spent. Cleaner data. Studies that close on time.
More participants reached. Less coordinator time spent. Cleaner data. Studies that close on time.
More participants reached. Less coordinator time spent. Cleaner data. Studies that close on time.
Fewer dropouts
Every participant who stays in the study is one you don't have to replace at full sponsor cost. Regular contact keeps participants connected before disengagement becomes withdrawal.
Hours back for your coordinators
Cleaner data, faster lock
Data you couldn't otherwise capture
Deployment speed
Cali keeps your patients close, so your team can focus on what only humans can do.
Contact Us
General inquiries: info@calico.care
© 2026 Calico.Care, Inc.
Cali keeps your patients close, so your team can focus on what only humans can do.
Contact Us
General inquiries: info@calico.care
© 2026 Calico.Care, Inc.
Cali keeps your patients close, so your team can focus on what only humans can do.
Contact Us
General inquiries: info@calico.care
© 2026 Calico.Care, Inc.